mSHOX2 Study Data
The potential for methylation analysis of the SHOX2 gene to improve the detection of lung cancer was demonstrated in a retrospective clinical case-control study with more than 500 patients suspected of having lung cancer.
Bronchial lavage samples were obtained from patients undergoing initial bronchoscopy. Disease cases were patients with histologically confirmed lung cancer and controls were patients with no evidence of lung cancer for at least one year following initial bronchoscopy.
The study was conducted in cooperation with the Charité University Medicine in Berlin, Germany and the Roy Castle Lung Cancer Foundation at the University of Liverpool in the United Kingdom.
As a prerequisite for CE-marking of the Epi proLung BL Reflex Assay, the performance characteristics of the test were validated in an additional retrospective clinical case-control study with 250 patients.
Moreover, we continue to work with our clinical partners on further mSHOX2 studies, including investigating the use of blood plasma as a clinical specimen.
